Myo - Inositol in women with PCOS
Myo – Inositol has demonstrated in combination with Folic Acid (the Vitamin B6) in clinical studies a significant improvement in testosterone, triglyceride and insulin levels (source: 1), factors associated with Polycystic Ovarian Syndorme (PCOS). The product called INOFOLIC® was used twice daily.
PCOS is one of the most common endocrine disorders in women and affects up to 20% of women of reproductive age (source: 2). Women showing features of this syndrome are often diagnosed with chronic oligomenorrhea or anovulation, hyperandrogenism and show a polycystic ovarian morphology (source: 3) .
It is not simply the ovarian abnormality that contributes to problems like abnormal cycles or even infertility. PCOS is associated with an increased risk of developing severe diseases like diabetes (source: 4) and heart diseases (source: 5). And PCOS is associated with insulin resistance in both, overweight and lean women (source: 6). Myo - Inositol, is a natural insulin sensitizer and can help restore a deficiency of intracellular metabolites in women with PCOS (source: 7). In addition to its role as insulin sensitizer, Myo - Inositol plays an important role in the follicular milieu, meiotic resumption and oocyte maturation as an intracellular messenger in mammalian oocytes (source: 8).
A clinical study has shown that women treated with Myo – Inositol in combination with Folic Acid (product called INOFOLIC®) had reduced androgen levels, helped restore ovulatory function, lowered blood pressure and decreased triglyceride levels (source: 1). This study confirms prior studies that have shown that Myo - Inositol administration improves endocrine parameters and insulin sensitivity. Myo - Inositol is a safe and effective natural medicine for improving insulin resistance (source: 9). Myo - Inositol should be recommended in conjunction with other positive lifestyle modifications like weight loss and dietary interventions for the management of PCOS and insulin resistance (source: 10).
The combination of Myo – Inositol and Folic Acid has proven
its important role at improving PCOS.
1. Gerli S, Mignosa M, Di Renzo GC. Effects of inositol on ovarian function and metabolic factors in women with PCOS: a randomized double blind placebo-controlled trial. Eur Rev Med Pharmacol Sci. 2003;7(6):151–159)
2. Knochenhauer ES, Key TJ, Kahsar-Miller M, Waggoner W, Boots LR, Azziz R. Prevalence of the polycystic ovary syndrome in unselected black and white women of the southeastern United States: a prospective study. J Clin Endocrinol Metab. 1998;83(9): 3078–3082)
3. Rotterdam ESHRE/ASRM-Sponsored PCOS wonsensus workshop group, Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS). Hum Reprod. 2004; 19(1): 41–47)
4. Legro RS, Kunselman AR, Dodson WC, Dunaif A. Prevalence and predictors of risk for type 2 diabetes mellitus and impaired glucose tolerance in PCOS: a prospective, controlled study in 254 affected women. J Clin Endocrinol Metab.1999;84(1):165–169)
5. Cattrall FR, Healy DL. Long-term metabolic, cardiovascular and neoplastic risks with polycystic ovary syndrome. Best Pract Res Clin Obstet Gynaecol. 2004;18(5):803–812)
6. Zawadsky JK, Dunaif A. Diagnostic criteria for polycystic ovary syndrome: towards a rational approach. In: Dunaif A, Givens JR, Haseltine FP, Merriam GR, editors. Current Issues in Endocrinology and Metabolism: PCOS. Cambridge, UK: Blackwell Scientific Publications; 1992: 377–384)
7. Genazzani AD, Lanzoni C, Ricchieri F, Jasonni VM. Myo - Inositol administration positively affects hyperinsulinemia and hormonal parameters in overweight patients with polycystic ovary syndrome, Gynecol Endocrinol. 2008;24:139–144)
8. Chiu TT, Rogers MS, Law EL, Briton-Jones CM, Cheung LP, Haines CJ: Follicular fluid and serum concentrations of myo-inositol in patients undergoing IVF: relationship with oocyte quality. Hum Reprod. 2002;17(6):1591–1596)
9. Carlomagno G, Unfer V: Inositol safety: clinical evidences. Eur Rev Med Pharmacol Sci. 2011;15(8):931–936)
10. Setareh Tais, ND, Myo - Inositol in Polycystic Ovarian Syndrome, (http://naturalmedicinejournal.com/journal/2013-08/myo-inositol-polycystic-ovarian-syndrome).